Objective: To examine changes in patients’ desired control of the deep brain stimulator and perception of global life control throughout DBS.Methods: A consecutive cohort of 52 patients with Parkinson’s disease was recruited to participate in a prospective longitudinal study over three assessment points. Semi-structured interviews assessing participants’ desire for stimulation control and perception of global control were conducted at all three points. Qualitative data were coded using content analysis. Visual analog scales were embedded in the interviews to quantify participants’ perceptions (...) of control over time.Results: Participants reported significant increases in their perception of global control over time and significant declines in their desired control of the stimulation. These changes were unrelated to improvements in motor symptoms. Improvements in global control were negatively correlated with a decline in desired stimulation control. Qualitative data indicate that participants have changed, nuanced levels of desired control over their stimulators. Increased global life control following DBS may be attributed to increased control over PD symptoms, increased ability to engage in valued activities, and increased overall self-regulation, while other domains related to global control remained unaffected by DBS.Conclusions: There are few empirical data documenting patients’ desire for stimulation control throughout neuromodulation and how stimulation control is related to other aspects of control despite the growing application of neuromodulation devices to treat a variety of disorders. Our data highlight distinctions in different types of control and have implications for the development of patient-controlled neurostimulation devices. (shrink)

To properly understand behavior, we must obtain both ultimate and proximate explanations. Put briefly, ultimate explanations are concerned with why a behavior exists, and proximate explanations are concerned with how it works. These two types of explanation are complementary and the distinction is critical to evolutionary explanation. We are concerned that they have become conflated in some areas of the evolutionary literature on human behavior. This article brings attention to these issues. We focus on three specific areas: the evolution of (...) cooperation, transmitted culture, and epigenetics. We do this to avoid confusion and wasted effort—dangers that are particularly acute in interdisciplinary research. Throughout this article, we suggest ways in which misunderstanding may be avoided in the future. (shrink)

In my 1993 IJPS paper it was suggested that postmodernist verdicts on ‘the death of philosophy’ relied on a rejection of any ‘substantive’ or ‘metaphysical’ notion of truth. The present paper relates these verdicts to Wittgenstein’s alleged ‘philosophical quietism’. In both cases, for example, there is a rejection of ‘depth’. Various characterisations of Wittgenstein’s position are questioned, including the idea that his quietism consists in showing the impossibility of sceptical challenges to our ‘hinge’ propositions and beliefs. It is then argued, (...) however, that recognition of the groundlessness of beliefs (and practices), far from curing ‘vertigo’ or ‘Angst’, is apt to inspire it. In a final section, I propose that the ‘metaphysical horror’ at the impossibility of articulating grounds for our beliefs can be allayed only by the thought that these answer to a reality that cannot be articulated and must therefore remain a mystery. One role for philosophy might be to cultivate a sense of this mystery and trace its implications for how we should live. (shrink)

Philosophers constantly discuss Responsibility. Yet in every discussion of which I am aware, a rather obvious point is ignored. The obvious point is that responsibility is ascribed to collectives, as well as to individual persons. Blaming attitudes are held towards collectives as well as towards individuals. Responsibility is often ascribed to nations, towns, clubs, groups, teams, and married couples. ‘Germany was responsible for the Second World War’; ‘The club as a whole is to blame for being relegated’. Such statements are (...) not rare. (shrink)

Traditionally, philosophical writings on personal identity have taken the form of attempts to discover the dominant criterion for deciding when a person at one time is identical with a person at some other time. Among the candidates for the role of dominant criterion have been bodily continuity and memory . In the normal case, where a person P is identical with a person P′ at an earlier time, it is true that P and P′ share a continuous body, that P (...) can remember experiences of P′, and that many other relationships hold between P and P′. Consequently, the debate as to which of the normal criteria is the dominant one has usually taken the form of imagining strange cases in which one or more of the normal criteria are lacking, and attempting to say, in such cases, who is identical with who. The scene was set, at least for modern times, by Locke's prince/pauper example, in which, according to Locke, the ability to remember experiences of a person having a different body guarantees, nevertheless, that one is that person—and hence that the memory criterion is dominant over the bodily identity one. (shrink)

David E. Cooper; I*—The Presidential Address: Analytical and Continental Philosophy, Proceedings of the Aristotelian Society, Volume 94, Issue 1, 1 June 1994, P.

This engaging volume explores and defends the claim that misanthropy is a justified attitude towards humankind in the light of how human beings both compare with and treat animals. Reflection on differences between humans and animals helps to confirm the misanthropic verdict, while reflection on the moral and other failings manifest in our treatment of animals illuminates what is wrong with this treatment. Human failings, it is argued, are too entrenched to permit optimism about the future of animals, but ways (...) are proposed in which individual people may accommodate to the truth of misanthropy through cultivating mindful, humble and compassionate relationships to animals. Drawing on both Eastern and Western philosophical traditions David E. Cooper offers an original and challenging approach to the complex field of animal ethics. (shrink)

Scholarly attempts to analyze the history of science sometime suffer from an imprecise use of terms. In order to understand accurately how science has developed and from where it draws its roots, researchers should be careful to recognize that epistemic regimes change over time and acceptable forms of knowledge production are contingent upon the hegemonic discourse informing the epistemic regime of any given period. In order to understand the importance of this point, I apply the techniques of historical epistemology to (...) an analysis of the place of the study of astrology in the medieval and early modern periods alongside a discussion of the “language games” of these period as well as the role of the “archeology of knowledge” in uncovering meaning in our study of the past. In sum, I argue that the term “science” should never be used when studying approaches to knowledge formation prior to the seventeenth century. (shrink)

An accountability-based privacy governance model is one where organizations are charged with societal objectives, such as using personal information in a manner that maintains individual autonomy and which protects individuals from social, financial and physical harms, while leaving the actual mechanisms for achieving those objectives to the organization. This paper discusses the essential elements of accountability identified by the Galway Accountability Project, with scholarship from the Centre for Information Policy Leadership at Hunton & Williams LLP. Conceptual _Privacy by Design_ principles (...) are offered as criteria for building privacy and accountability into organizational information management practices. The authors then provide an example of an organizational control process that uses the principles to implement the essential elements. Initially developed in the ‘90s to advance privacy-enhancing information and communication technologies, Dr. Ann Cavoukian has since expanded the application of _Privacy by Design_ principles to include business processes. (shrink)

Several metabolites serve as substrates for histone modifications and communicate changes in the metabolic environment to the epigenome. Technologies such as metabolomics and proteomics have allowed us to reconstruct the interactions between metabolic pathways and histones. These technologies have shed light on how nutrient availability can have a dramatic effect on various histone modifications. This metabolism–epigenome cross talk plays a fundamental role in development, immune function, and diseases like cancer. Yet, major challenges remain in understanding the interactions between cellular metabolism (...) and the epigenome. How the levels and fluxes of various metabolites impact epigenetic marks is still unclear. Discussed herein are recent applications and the potential of systems biology methods such as flux tracing and metabolic modeling to address these challenges and to uncover new metabolic–epigenetic interactions. These systems approaches can ultimately help elucidate how nutrients shape the epigenome of microbes and mammalian cells. (shrink)

The basal and reciprocal models of the relationship between androgen secretion and dominance are not mutually exclusive. Individuals may differ in basal levels of androgen secretion, reactivity to experiences, and androgen sensitivity. Early experiences might affect any of these parameters.

In lieu of an abstract, here is a brief excerpt of the content:Philosophy, Psychiatry, & Psychology 10.4 (2003) 369-372 [Access article in PDF] Unity of Agency and Volition:Some Personal Reflections Stephen Weiner The issues of unity of agency, self-as-narrative, and more generally, volition are highly personal to me. Indeed, I would say I have frequently been obsessed with them. I am 52 years old, and date the onset of my psychiatric symptoms—my long-term misery—very specifically: 11:00 pm Pacific Standard Time, August (...) 28, 1965. At almost precisely that time, I started obsessing that I was homosexual and, in fact, turning into a girl. Within days, derealization followed: for instance, the houses in my neighborhood seemed one-dimensional—they seemed as though they were painted, as though I could stick my hand or an object through them. Colors seemed less bright as well—but I hardly had words for all this at the time: it was an overwhelmingly preverbal feeling, but I found some words for it.I was also depressed, and knew I was depressed—that is, I was worried, had trouble sleeping, and had suicidal thoughts and feelings. Within weeks, I asked my parents if I could see a psychiatrist, and I did. I remember asking my psychiatrist if he ever thought about the possibility that everything might be an illusion, and he quoted the refrain from "Row, Row, Row Your Boat": "merrily, merrily, merrily, merrily, life is but a dream." But just asking him produced a chilling feeling that he did not exist and, largely for this reason, I did not mention unreality feelings again to therapists for another 20 years.So, like Dr. Wells' patient Edward, described by James Phillips (2003), I was in trouble; like Edward, I was starting to construct a narrative. I started feeling that I had "to tell my story" at about this time—before then, I had not felt a need to do that. That may be partly because young children take life for granted (at least, I did), and it may be partly because suffering, by its very nature, demands explanation; both reasons were probably operating—certainly, both my parents told me years later that I had seemed emotionally distressed as a child, and my mother told they would have given me Ritalin if it had been available. So, to other people (my parents and my teachers) I was mentally ill in some sense, and I have some pretty clear memories of what I now recognize as depression, especially in the second and third grades; but I did not think of myself as sick and I did not think of myself as suffering—and I did not experience the duality (at least) of selves that I started to experience almost immediately in August 1965.Phillips further points out that the "future Edward" could look back in his narrative, at a later age, and reconstruct his history either as someone with a continuing mental illness, or as someone who had attained a secure, healthy adulthood and saw his experience as adolescent pain in the service of ultimate adult health and integration. I see my story, I am sorry to report, as [End Page 369] one of unremitting basic pain but with the positive dimension that I was able to go on, obtain a good education, work a good deal in my adult life, and father a child. But my narrative—and am I not, as a highly verbal person, almost constrained to think of my life as a narrative?—has been one, as Phillips (following Kleinman) realizes, of suffering. It is, above all else, an illness narrative. I find the approach of J. Melvin Woody (2003)—of privileging performing and performing arts and spatial metaphors over story—less relevant and true to myself, although I see no reason to argue with Mary's preference for such forms. It may be that the temporal discontinuities she has experienced predispose her to see herself in such terms—may, in fact, necessitate doing so. I am not exactly sure why, but it probably has to do with acting, with trying on and performing one role... (shrink)

Two key phenomena of Merleau-Ponty's _Phenomenology of Perception are habit and inhabiting. Their chief characteristics, respectively, are generalizing actions and actively familiarizing. They are essentially and reciprocally related: inhabiting consists of being in habits and habitual actions are a way of inhabiting. The article focuses on three aspects of Merleau-Ponty's discussions: habit as simultaneously motor and perceptual, the interplay of sedimentation and spontaneity, and the body's inhabiting of space and incorporating of expressive spatiality. Merleau-Ponty's typist example and four examples of (...) the author illustrate that the relationship of habit and inhabiting is a basic structure of being-in-the-world. (shrink)

The task of designing effective economic and political institutions requires substantial foresight. The designer must anticipate not only the behavior of individual actors, but also how that behavior will aggregate. Rising complexity brought about by increases in speeds of adaptation, diversity, connectedness, and interdependence make institutional design all the more challenging. Given the focus on equilibria, the extant literature on mechanism design might appear incapable of coping with this complexity. Yet, I suggest that a deeper engagement with the origins of (...) the mechanism-design framework reveals insights that may help us design robust, adaptive institutions that can harness complexity. (shrink)

By addressing specific global problems and placing them within an ethical context, "The Environment in Question" provides the reader with both a theoretical and practical understanding of environmental issues. The contributors are internationally known figures drawn from the various disciplines which bear upon these issues, such as geography, psychology, social policy, and philosophy. The contributions range from those tackling individual concrete issues (such as nuclear waste and the threat to the rain forest) to those addressing matters of policy, principle and (...) attitude (such as our obligations to future generations and the nature of technological risk). "The Environment in Question" is designed as a text for students of philosophy, environmental science, environmental education, ecology, and teacher education. It can be used as an inter-disciplinary, self-contained course book or in conjunction with relevant material. In addition, as the essays directly and controversially address current environmental debates in a non-technical manner, it is of great interest both to professionals in those areas and to readers who care about the planet's future. The substantial cross-section of concerns and approaches will enable all readers to develop the necessary level of understanding required to initiate and sustain debate on environmental issues. Contributors: Robert Allsion, David E. Cooper, Barry S. Gower, F. G. T. Holliday, C. A. Hooker, Mary Midgley, Philip Neal, Joy A. Palmer, Robert Prosser, Holmes Rolston III, Mark Sagoff, Vandana Shiva, Stephen Sterling, Rosemary J. Stevenson, Jennifer Trusted. (shrink)

Characterizations of philosophy abound. It is ‘the queen of the sciences’, a grand and sweeping metaphysical endeavour; or, less regally, it is a sort of deep anthropology or ‘descriptive metaphysics’, uncovering the general presuppositions or conceptual schemes that lurk beneath our words and thoughts. A different set of images portray philosophy as a type of therapy, or as a spiritual exercise, a way of life to be followed, or even as a special branch of poetry or politics. Then there is (...) a group of characterizations that include philosophy as linguistic analysis, as phenomenological description, as conceptual geography, or as genealogy in the sense proposed by Nietzsche and later taken up by Foucault. (shrink)

Consensus plays an ambiguous role in deliberative democracy. While it formed the horizon of early deliberative theories, many now denounce it as an empirically unachievable outcome, a logically impossible stopping rule, and a normatively undesirable ideal. Deliberative disagreement, by contrast, is celebrated not just as an empirically unavoidable outcome but also as a democratically sound and normatively desirable goal of deliberation. Majority rule has generally displaced unanimity as the ideal way of bringing deliberation to a close. This article offers an (...) epistemic perspective on this question of consensus versus disagreement. For ensuring the production of better decisions, we argue, the normative appeal of consensus varies depending on the deliberative task – whether it entails problem solving or prediction. We argue that in pure problem-solving contexts, consensus retains a strong normative appeal and forms the ideal deliberative outcome of deliberation. In contrast, on predictive tasks, consensus should generally not be used as a stopping rule noris it likely to be epistemically desirable as an outcome. Instead deliberators may be better served by ending the deliberation with a form of deliberative disagreement we call ‘positive dissensus’, which paves the way for more accurate aggregate predictions. (shrink)

‘Reactionary modernism’ is a term happily coined by the historian and sociologist Jeffrey Herf to refer to a current of German thought during the interwar years. It indicates the attempt to ‘reconcil[e] the antimodernist, romantic and irrationalist ideas present in German nationalism’ with that ‘most obvious manifestation of means–ends rationality … modern technology’. Herf's paradigm examples of this current of thought are two best-selling writers of the period: Oswald Spengler, author of the massive domesday scenario The Decline of the West (...) in 1917 and, fifteen years later, of Man and Technics, and Ernst Jünger, the now centenarian chronicler of the war in which he was a much-decorated hero, whose main theoretical work was Der Arbeiter in 1932. The label is also applied by Herf to such intellectual luminaries as the legal theorist and apologist for the Third Reich, Carl Schmitt, and more contentiously Martin Heidegger. At a less elevated level, reactionary modernism also permeated the writings of countless, now forgotten engineers, who were inspired at once by the new technology, Nietzschean images of Promethean Übermenschen, and an ethos of völkisch nationalism. (shrink)

Second harmonic generating (SHG) nanoprobes have recently emerged as versatile and durable labels suitable for in vivo imaging, circumventing many of the inherent drawbacks encountered with classical fluorescent probes. Since their nanocrystalline structure lacks a central point of symmetry, they are capable of generating second harmonic signal under intense illumination – converting two photons into one photon of half the incident wavelength – and can be detected by conventional two‐photon microscopy. Because the optical signal of SHG nanoprobes is based on (...) scattering, rather than absorption as in the case of fluorescent probes, they neither bleach nor blink, and the signal does not saturate with increasing illumination intensity. When SHG nanoprobes are used to image live tissue, the SHG signal can be detected with little background signal, and they are physiologically inert, showing excellent long‐term photostability. Because of their photophysical properties, SHG nanoprobes provide unique advantages for molecular imaging of living cells and tissues with unmatched sensitivity and temporal resolution. (shrink)

Educational policy and discussion, in Britain and the USA, are increasingly dominated by the confused ideology of egalitarianism. David E. Cooper begins by identifying the principles hidden among the confusions, and argues that these necessarily conflict with the ideal of educational excellence - in which conflict it is this ideal that must be preserved. He goes on to criticize the use of education as a tool for promoting wider social equality, focussing especially on the muddles surrounding 'equal opportunities', 'social (...) mix' and 'reverse discrimination'. Further chapters criticize the 'new egalitarianism' favoured, on epistemological grounds, by various sociologists of knowledge in recent years and 'cultural egalitarianism' according to which standard criteria of educational value merely reflect parochial and economic interests. (shrink)

Buddhism, one increasingly hears, is an 'eco-friendly' religion. It is often said that this is because it promotes an 'ecological' view of things, one stressing the essential unity of human beings and the natural world. Buddhism, Virtue and Environment presents a different view. While agreeing that Buddhism is, in many important respects, in tune with environmental concerns, Cooper and James argue that what makes it 'green' is its view of human life. The true connection between the religion and environmental (...) thought is to be found in Buddhist accounts of the virtues - those traits, such as compassion, equanimity and humility, that characterise the life of a spiritually enlightened individual. Central chapters of this book examine these virtues and their implications for environmental attitudes and practice. Buddhism, Virtue and Environment will be of interest not only to students and teachers of Buddhism and environmental ethics, but to those more generally engaged with moral philosophy. Written in a clear and accessible style, this book presents an original conception of Buddhist environmental thought. The authors also contribute to the wider debate on the place of ethics in Buddhist teachings and practices, and to debates within 'virtue ethics' on the relations between human well-being and environmental concern. (shrink)

This paper defends the description of Buddhism—by Schopenhauer and many other nineteenth-century figures—as pessimistic. Pessimism, in the relevant sense, is a dark, negative judgment on the psychological, social, and moral condition of humankind and the prospects for its amelioration. After discussing texts in the Pali canon that provide prima facie support for the charge of pessimism, two familiar responses are considered. One emphasizes the positive aspects of the human condition recognized by the Buddha; the other emphasizes the prospect held out (...) by him for the cessation of dukkha. It is argued that neither response is persuasive—not least because of a failure to appreciate the gulf between ordinary “worldling” existence and that of the arahant or enlightened person. A final section discusses the description of the arahant as “transcending the world” and the human condition. If correct, this supports the charge of pessimism. This is because pessimism is a claim about the human condition, about our being-in-the-world, and cannot therefore be refuted by the prospect of a mode of being that transcends this condition. (shrink)

We shall argue that there is adequate moral justification for capital punishment with linkage, that is, with linkage to keeping non‐murderers from dying. We present the argument with two aims in mind. The first is to question the conventional wisdom, seldom challenged even by proponents of capital punishment, that being an abolitionist is closely connected to having a civilized respect for human life. This conventional wisdom, we hope to show, is somewhat off the mark. To this end we exhibit structural (...) similarities between so‐called lifeboat dilemmas and the public's relationship to a murderer. In a lifeboat dilemma one must choose between saving this life or that, since the lifeboat will not hold both persons. Now if this life were an innocent's and that one a murderer's, a choice to save the latter would not be met with accusations of callousness towards human life. We hope to project everyone's intuitions about this case onto the more baffling case of a society's relationship to the murderers and dying innocents in its midst. (shrink)

It is by now something of a cliché of Green discourse that environmental degradation and devastation is grounded in a sharp opposition – the legacy, it is often charged, of Christian metaphysics – between the human and the non-human, between the realms of culture and nature. If one is to understand, let alone endorse, the very general environmentalist ambition to dissolve the dualism of the human and the non-human, it is by questioning rather more tractable and particular dichotomies, like that (...) between art and nature appreciation, where it would seem wise to begin. (shrink)

R. S. Peters has not only been the major philosopher of education in Britain during second half of the twentieth century, but by common consent, he has transformed the subject and brought it into the mainstream of contemporary philosophy. The ten essays in this book attest to his influence whether by critical examination of his ideas or by original treatment of topics in which has has inspired a new interest.